http://www.rssboard.org/rss-specification 720 http://xtf.cdlib.org:8080/xtf/search?subject%3DResearch%20Article;subject-join%3Dexact;smode%3Dsimple;brand%3Ddefault Results for your query: subject=Research Article;subject-join=exact;smode=simple;brand=default Thu, 15 Dec 2005 12:00:00 GMT http://xtf.cdlib.org:8080/xtf/view?docId=nlm/bmc/bmc.xml Background Different classes of haplotype block algorithms exist and the ideal dataset to assess their performance would be to comprehensively re-sequence a large genomic region in a large population. Such data sets are expensive to collect. Alternatively, we performed coalescent simulations to generate haplotypes with a high marker density and compared block partitioning results from diversity based, LD based, and information theoretic algorithms under different values of SNP density and allele frequency. Results We simulated 1000 haplotypes using the standard coalescent for three world populations – European, African American, and East Asian – and applied three classes of block partitioning algorithms – diversity based, LD based, and information theoretic. We assessed algorithm differences in number, size, and coverage of blocks inferred under different conditions of... http://xtf.cdlib.org:8080/xtf/view?docId=nlm/bmc/bmc.xml Thu, 01 Jan 1970 12:00:00 GMT